Drug dissolution tests are routinely conducted to evaluate drug release characteristics of pharmaceutical products such as tablets and capsules. It is highly desirable that these tests should be conducted to reflect in vivo drug release which in turn is reflected by the observed plasma drug conc.-time (C-t) profiles in humans.
In this regard, a simple convolution based method using spreadsheet software has been suggested to convert dissolution results into C-t profiles (link1, link2). This article provides another example describing estimation of plasma drug levels from OROS-based nifedipine products using the suggested convolution approach.
