IVIVC is commonly referred to as having an in vitro dissolution method which is able to relate dissolution or absorption properties of a drug in vivo, mostly in humans. It is further assumed that an analyst will be using a paddle or basket apparatus for developing such IVIVC. On the other hand, it is interesting to note that the use of paddle and basket apparatuses has never been validated for establishing IVIVC i.e. whether, or not, these apparatuses are capable of providing relevant in vivo results. Successful examples of such IVIVC are rare, if any. More recent literature highlights that lack of an appropriate stirring/mixing environment within dissolution vessels for these apparatuses may NOT properly reflect in vivo (or bio-relevant) environment thus demonstrating their inability to provide IVIVC.
Therefore, when considering developing IVIVC, or evaluating published literature/studies in this regard, one should be cautious as conclusion drawn could be misleading and/or errounous.
