It is often debated as to which approach is better or more appropriate for calibration or standardization of the apparatuses. It appears that calibration may not be a critical or important step, at present. The reason being, even if the apparatuses (paddle and basket) are adequately calibrated using any of the two approaches, they still would show lack of relevance of results and provide very high variability in dissolution results.
It has been shown from experimental studies and computer simulation modeling that paddle and basket apparatuses provide poor hydrodynamics, thus results obtained from these apparatuses would be of limited value and use. As a results the calibration aspect becomes secondary.
